ORMDL3 and REEP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ORMDL3	REEP2
Description		ORMDL sphingolipid biosynthesis regulator 3	receptor accessory protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane SPOTS Complex Specific Granule Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Integral Component Of Plasma Membrane Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Taste Receptor Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Myelination Motor Behavior Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Serine C-palmitoyltransferase Activity	Regulation Of Intracellular Transport Protein Transport Into Membrane Raft Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Endoplasmic Reticulum Tubular Network Organization
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation	Olfactory Signaling Pathway
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 31959851 31619474 21150878 29273806 28461288 17611496 22561531) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 18587394 28067908 21102463) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 30659077 21829393 25751624 19430480) Ulcerative colitis ( 28067908 20228799 21297633) White blood cell count ( 27863252 21738480)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 25056061)
Interacting Genes		35 interacting genes: APP AQP6 ARL13B C10orf67 CCR7 CDC27 CERS3 COQ8A CRHR1 EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 KRT13 LEPROTL1 LMNA LNX1 MED1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35C2 SLC7A1 SYT2 TMEM237	25 interacting genes: BNIP3 C2CD2L CMTM5 CYP4F2 CYP4F22 ITGAM KDM3B MS4A1 MUL1 NAT8 ORMDL3 RABAC1 SCD SFT2D2 SLC25A46 TMBIM6 TMEM120B TMEM208 TMEM239 TMEM31 TMEM42 TMEM60 TMX2 TTPA YIF1A
Entrez ID		94103	51308
HPRD ID		17803	16655
Ensembl ID		ENSG00000172057	ENSG00000132563
Uniprot IDs		A0A024R1W6 Q8N138	A8K3D2 Q9BRK0
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0M 7K0N 7K0O 7K0P 7K0Q
Enriched GO Terms of Interacting Partners?
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