ORMDL3 and MED1

		ORMDL3	MED1
Description		ORMDL sphingolipid biosynthesis regulator 3	mediator complex subunit 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane SPOTS Complex Specific Granule Membrane	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding LBD Domain Binding Ubiquitin Protein Ligase Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of B Cell Apoptotic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Myelination Motor Behavior Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Serine C-palmitoyltransferase Activity	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Generation Protein Import Into Nucleus Androgen Biosynthetic Process Brain Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Enucleate Erythrocyte Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Generic Transcription Pathway Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression Cytoprotection by HMOX1 Heme signaling
Drugs			Becocalcidiol
Diseases
GWAS		Adult asthma ( 30787307) Asthma ( 31959851 31619474 21150878 29273806 28461288 17611496 22561531) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 18587394 28067908 21102463) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 30659077 21829393 25751624 19430480) Ulcerative colitis ( 28067908 20228799 21297633) White blood cell count ( 27863252 21738480)	Asthma ( 31619474) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Lung function (FVC) ( 30061609) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 20228799)
Interacting Genes		35 interacting genes: APP AQP6 ARL13B C10orf67 CCR7 CDC27 CERS3 COQ8A CRHR1 EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 KRT13 LEPROTL1 LMNA LNX1 MED1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35C2 SLC7A1 SYT2 TMEM237	49 interacting genes: AKAP9 AR BRCA1 CASK CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A HRK KIF1A MAPK3 MDM2 MED12 MED14 MED25 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 ORMDL3 PIN1 PPARA PPARG PPARGC1A PSMD3 RARA RBM5 RORA RPA2 RXRA SREBF1 TET2 THRA THRB TP53 VDR YWHAH YWHAQ
Entrez ID		94103	5469
HPRD ID		17803	05055
Ensembl ID		ENSG00000172057	ENSG00000125686
Uniprot IDs		A0A024R1W6 Q8N138	Q15648
PDB IDs		6M4N 6M4O 7CQI 7CQK 7K0M 7K0N 7K0O 7K0P 7K0Q	1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W0G 3W0H 3W0I 3W0J 3W5P 3W5Q 3W5R 3W5T 3WT5 3WT6 3WT7 3WTQ 4YNK 5AWJ 5AWK 5B41 5B5B 5GIC 5GID 5GIE 5XPM 5XPN 5XPO 5XPP 5XUQ 5XZF 5XZH 5ZWE 5ZWF 5ZWH 5ZWI 6D94 6JEZ 6K5O 6ONJ 7C7V 7C7W
Enriched GO Terms of Interacting Partners?
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