USP8 and NTRK2

Number of citations of the paper that reports this interaction (PubMedID 33288548)
0

Data Source:
BioGRID (enzymatic study)

		USP8	NTRK2
Description		ubiquitin specific peptidase 8	neurotrophic receptor tyrosine kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine Glutamatergic Synapse	Early Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendrite Early Endosome Membrane Terminal Bouton Dendritic Spine Receptor Complex Axon Terminus Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding SH3 Domain Binding Cadherin Binding	Protease Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Neurotrophin Receptor Activity Protein Binding ATP Binding Protein Homodimerization Activity Neurotrophin Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	Mitotic Cytokinesis Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cellular Response To Nerve Growth Factor Stimulus	Vasculogenesis Neuron Migration Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Learning Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Neuronal Action Potential Propagation Central Nervous System Neuron Development Cerebral Cortex Development Myelination In Peripheral Nervous System Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Kinase Activity Neurotrophin Signaling Pathway Mechanoreceptor Differentiation Regulation Of GTPase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Synapse Assembly Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Amino Acid Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Trans-synaptic Signaling By Neuropeptide, Modulating Synaptic Transmission Negative Regulation Of Amyloid-beta Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus Negative Regulation Of Anoikis
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	NGF-independant TRKA activation BDNF activates NTRK2 (TRKB) signaling NTF3 activates NTRK2 (TRKB) signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FYN NTRK2 activates RAC1 NTRK2 activates RAC1 Activated NTRK2 signals through CDK5
Drugs			Amitriptyline Esketamine Entrectinib Fostamatinib Larotrectinib
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)	Birth weight ( 24950379) Body mass index ( 28892062 25760438) Body size at age 10 ( 32376654) Gout (normal type) ( 32238385) Lifetime anxiety disorder ( 31748690) Menarche (age at onset) ( 25231870) Parkinson's disease progression (cognitive) ( 33111402) Refractive error ( 32231278) Serum metabolite concentrations in chronic kidney disease ( 29545352) Type 2 diabetes ( 31118516) Waist-to-hip circumference ratio (recreational physical activity interaction) ( 23192594)
Interacting Genes		43 interacting genes: BACE1 BIRC6 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 EPS15 GNAL GRAP2 GRB2 H2AC20 H2BC21 KIF23 NBR1 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	38 interacting genes: AP1B1 BDNF CDK20 DOK5 DYNLL1 EGFR ERBB2 ERBB4 FRS2 FRS3 FYN GIPC1 KCNS1 KIDINS220 NCK1 NCK2 NDFIP1 NGFR NMNAT1 NTF3 NTF4 NXNL2 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SORT1 SQSTM1 TRAF6 UBB USP8
Entrez ID		9101	4915
HPRD ID		04405	02712
Ensembl ID		ENSG00000138592	ENSG00000148053
Uniprot IDs		A0A024R5S4 A8K8N5 P40818	A0A024R230 Q16620 Q548C2 Q5VWE5
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09	1HCF 1WWB 2MFQ 4ASZ 4AT3 4AT4 4AT5 5MO9
Enriched GO Terms of Interacting Partners?
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