DIRAS3 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		DIRAS3	PALB2
Description		DIRAS family GTPase 3	partner and localizer of BRCA2
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GO Annotations	Cellular Component	Plasma Membrane	Nucleoplasm Protein-containing Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	DNA Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression By Genetic Imprinting Small GTPase Mediated Signal Transduction	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS			Bipolar disorder ( 17554300)
Interacting Genes		14 interacting genes: ACADM APC BAG4 BRMS1 CHEK2 FGFR4 HTR2A KRAS MEOX2 PALB2 PPM1D PTPN1 TGFB1 WT1	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		9077	79728
HPRD ID		05547	07966
Ensembl ID		ENSG00000162595	ENSG00000083093
Uniprot IDs		O95661	H3BN63 Q86YC2
PDB IDs		6NAZ	2W18 3EU7
Enriched GO Terms of Interacting Partners?
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