CLDN12 and ECHS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		CLDN12	ECHS1
Description		claudin 12	enoyl-CoA hydratase, short chain 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Lateral Plasma Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Identical Protein Binding	Enoyl-CoA Hydratase Activity Protein Binding 3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity
	Biological Process	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Maintenance Of Blood-brain Barrier Tight Junction Assembly	Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process
Pathways		Tight junction interactions	Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs			Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)cinnamoyl-CoA Omega-3-carboxylic acids
Diseases
GWAS			Lifespan ( 25918517) Nonunion in individuals with fractures ( 30680360) Serum metabolite levels ( 33031748)
Interacting Genes		4 interacting genes: ECHS1 SEC13 STRN4 TRARG1	14 interacting genes: CAPN1 CBWD2 CDC42 CLDN12 CYP2E1 ERCC6 FXR1 FXR2 GRB2 LRRK1 LRRK2 PPM1B SERPINA1 UBA1
Entrez ID		9069	1892
HPRD ID		13064	03799
Ensembl ID		ENSG00000157224	ENSG00000127884
Uniprot IDs		B2R687 P56749	P30084
PDB IDs			2HW5
Enriched GO Terms of Interacting Partners?
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