ECHS1 and PPM1B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ECHS1	PPM1B
Description		enoyl-CoA hydratase, short chain 1	protein phosphatase, Mg2+/Mn2+ dependent 1B
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleus Nucleolus Cytosol Membrane
	Molecular Function	Enoyl-CoA Hydratase Activity Protein Binding 3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA	ISG15 antiviral mechanism ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs		Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)cinnamoyl-CoA Omega-3-carboxylic acids
Diseases
GWAS		Lifespan ( 25918517) Nonunion in individuals with fractures ( 30680360) Serum metabolite levels ( 33031748)	Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		14 interacting genes: CAPN1 CBWD2 CDC42 CLDN12 CYP2E1 ERCC6 FXR1 FXR2 GRB2 LRRK1 LRRK2 PPM1B SERPINA1 UBA1	22 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAD2L2 MAP3K7 MSN MYL7 NCOA1 PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2
Entrez ID		1892	5495
HPRD ID		03799	04796
Ensembl ID		ENSG00000127884	ENSG00000138032
Uniprot IDs		P30084	O75688
PDB IDs		2HW5	2P8E
Enriched GO Terms of Interacting Partners?
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