ECHS1 and CLDN12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ECHS1	CLDN12
Description		enoyl-CoA hydratase, short chain 1	claudin 12
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Lateral Plasma Membrane
	Molecular Function	Enoyl-CoA Hydratase Activity Protein Binding 3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity	Protein Binding Identical Protein Binding
	Biological Process	Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Maintenance Of Blood-brain Barrier Tight Junction Assembly
Pathways		Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA	Tight junction interactions
Drugs		Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)cinnamoyl-CoA Omega-3-carboxylic acids
Diseases
GWAS		Lifespan ( 25918517) Nonunion in individuals with fractures ( 30680360) Serum metabolite levels ( 33031748)
Interacting Genes		14 interacting genes: CAPN1 CBWD2 CDC42 CLDN12 CYP2E1 ERCC6 FXR1 FXR2 GRB2 LRRK1 LRRK2 PPM1B SERPINA1 UBA1	4 interacting genes: ECHS1 SEC13 STRN4 TRARG1
Entrez ID		1892	9069
HPRD ID		03799	13064
Ensembl ID		ENSG00000127884	ENSG00000157224
Uniprot IDs		P30084	B2R687 P56749
PDB IDs		2HW5
Enriched GO Terms of Interacting Partners?
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