APLN and APLNR

Number of citations of the paper that reports this interaction (PubMedID 12603839)
100

Data Source:
HPRD (in vivo)

		APLN	APLNR
Description		apelin	apelin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Apelin Receptor Binding Identical Protein Binding	G Protein-coupled Receptor Activity Protein Binding Signaling Receptor Activity Apelin Receptor Activity
	Biological Process	Angiogenesis Regulation Of The Force Of Heart Contraction Negative Regulation Of Systemic Arterial Blood Pressure Immune Response Signal Transduction Gastrulation Lactation Positive Regulation Of Heart Rate Negative Regulation Of Gene Expression Positive Regulation Of Heat Generation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Drinking Behavior Negative Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Negative Regulation Of Vasoconstriction Positive Regulation Of Corticotropin Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping Atrioventricular Valve Development Endocardial Cushion Formation G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Histone Deacetylation Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of Inhibitory G Protein-coupled Receptor Phosphorylation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: APLNR GET3 MDFI PLSCR4 PSMA3 RBPMS TRIM55 TRIM63	8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3
Entrez ID		8862	187
HPRD ID		02246	02503
Ensembl ID		ENSG00000171388	ENSG00000134817
Uniprot IDs		Q9ULZ1	B2RDH3 B3KQN4 P35414
PDB IDs			2LOT 2LOU 2LOV 2LOW 5VBL 6KNM
Enriched GO Terms of Interacting Partners?
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