APLNR and SETD3

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		APLNR	SETD3
Description		apelin receptor	SET domain containing 3, actin histidine methyltransferase
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Chromatin Nucleoplasm Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Signaling Receptor Activity Apelin Receptor Activity	Transcription Coactivator Activity Actin Binding Protein Binding Protein-lysine N-methyltransferase Activity Protein-L-histidine N-tele-methyltransferase Activity Histone Methyltransferase Activity (H3-K4 Specific) Histone Methyltransferase Activity (H3-K36 Specific) RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping Atrioventricular Valve Development Endocardial Cushion Formation G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Histone Deacetylation Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of Inhibitory G Protein-coupled Receptor Phosphorylation	Histone H3-K36 Methylation Peptidyl-histidine Methylation Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Actin Modification Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Muscle Cell Differentiation Histone H3-K4 Methylation Regulation Of Uterine Smooth Muscle Contraction
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	4 interacting genes: APLNR APP MYOD1 SRPK1
Entrez ID		187	84193
HPRD ID		02503	08664
Ensembl ID		ENSG00000134817	ENSG00000183576
Uniprot IDs		B2RDH3 B3KQN4 P35414	A0A024R6K3 Q86TU7
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM	3SMT 6ICT 6ICV 6JAT 6MBJ 6MBK 6MBL 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2
Enriched GO Terms of Interacting Partners?
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