ASAP2 and RRM2

		ASAP2	RRM2
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	ribonucleotide reductase regulatory subunit M2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Golgi Cisterna Membrane	Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of GTPase Activity	Blastocyst Development DNA Replication Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization
Pathways			Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs			Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 30804561) Chronic widespread musculoskeletal pain ( 33331911) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)	Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)
Interacting Genes		15 interacting genes: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 RRM2 SH3KBP1 THSD7A	19 interacting genes: ASAP2 BARX1 CDH1 CDK1 DNM1L GCG ITSN2 KAT5 LAPTM4A LPIN1 MGAT4A NPBWR2 PLK3 RRM1 RRM2B SDCBP ST3GAL3 TAF1B TP53
Entrez ID		8853	6241
HPRD ID		04820	01587
Ensembl ID		ENSG00000151693	ENSG00000171848
Uniprot IDs		O43150	P31350
PDB IDs			2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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