RRM2 and ST3GAL3

		RRM2	ST3GAL3
Description		ribonucleotide reductase regulatory subunit M2	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Ribonucleoside-diphosphate Reductase Complex	Golgi Membrane Extracellular Region Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity
	Biological Process	Blastocyst Development DNA Replication Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization	Protein Glycosylation Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide O-glycan Processing Keratan Sulfate Biosynthetic Process Viral Protein Processing Sialylation
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Aging (time to event) ( 21782286) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Attention deficit hyperactivity disorder ( 29325848) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) General cognitive ability ( 29844566) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Left-handedness ( 32989287) Monocyte percentage of white cells ( 32888494) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377) Refractive error ( 32231278) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		19 interacting genes: ASAP2 BARX1 CDH1 CDK1 DNM1L GCG ITSN2 KAT5 LAPTM4A LPIN1 MGAT4A NPBWR2 PLK3 RRM1 RRM2B SDCBP ST3GAL3 TAF1B TP53	19 interacting genes: ACTG1 CAVIN2 EIF2B3 FBLN5 HDAC5 KCNQ4 KDM4A LASP1 MOB3B NASP PIK3R3 POU3F1 RPL8 RRM2 SCAMP2 TGFB1I1 TTR VTI1A ZBTB5
Entrez ID		6241	6487
HPRD ID		01587	05930
Ensembl ID		ENSG00000171848	ENSG00000126091
Uniprot IDs		P31350	A0A2R8Y732 Q11203
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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