NUMB and PALS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NUMB	PALS1
Description		NUMB endocytic adaptor protein	protein associated with LIN7 1, MAGUK p55 family member
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GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Apical Plasma Membrane Axon Protein-containing Complex Myelin Sheath Adaxonal Region Perikaryon Lateral Loop Schmidt-Lanterman Incisure Extracellular Exosome
	Molecular Function	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	Protein Binding ATP Binding Protein Domain Specific Binding
	Biological Process	Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane	Morphogenesis Of An Epithelial Sheet Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Protein Localization To Plasma Membrane
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state	Tight junction interactions
Drugs
Diseases
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Hemoglobin ( 32888494) Macular thickness ( 30535121) Multisite chronic pain ( 33830993 31194737) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		36 interacting genes: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2	17 interacting genes: ARF6 BHLHB9 CRB3 DLGAP4 FTCD LIN7A LIN7B LIN7C MPP4 NEK9 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2
Entrez ID		8650	64398
HPRD ID		04767	09508
Ensembl ID		ENSG00000133961	ENSG00000072415
Uniprot IDs		A0A024R681 A0A024R684 A0A024R6C4 A0A024R6F4 P49757	Q658X5 Q8N3R9
PDB IDs		5NJJ 5NJK	1Y76 3UIT 4UU5 4UU6 4WSI
Enriched GO Terms of Interacting Partners?
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