PPM1D and DKK3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		PPM1D	DKK3
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	dickkopf WNT signaling pathway inhibitor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol	Extracellular Space
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Co-receptor Binding Receptor Antagonist Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Anatomical Structure Morphogenesis Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Gland Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Signaling Receptor Activity
Pathways		Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Blood protein levels ( 30072576 29875488) Cortical volume ( 32963231) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Response to perphenazine in schizophrenia ( 29503163) Response to taxane treatment (docetaxel) ( 23006423) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		25 interacting genes: ATP6V1A BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	12 interacting genes: APC AURKA BCAR3 ESR2 FZR1 HOXA1 IDH1 NUFIP2 PPM1D SGTA SMAD4 UBQLN4
Entrez ID		8493	27122
HPRD ID		05482	05659
Ensembl ID		ENSG00000170836	ENSG00000050165
Uniprot IDs		A0A0S2Z4M2 O15297	F6SYF8 Q9UBP4
PDB IDs
Enriched GO Terms of Interacting Partners?
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