DKK3 and BCAR3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		DKK3	BCAR3
Description		dickkopf WNT signaling pathway inhibitor 3	BCAR3 adaptor protein, NSP family member
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Cytoplasm Focal Adhesion Membrane
	Molecular Function	Protein Binding Co-receptor Binding Receptor Antagonist Activity	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding
	Biological Process	Anatomical Structure Morphogenesis Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Adrenal Gland Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Signaling Receptor Activity	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Cortical volume ( 32963231) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Response to perphenazine in schizophrenia ( 29503163) Response to taxane treatment (docetaxel) ( 23006423) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 34021172)	Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)
Interacting Genes		12 interacting genes: APC AURKA BCAR3 ESR2 FZR1 HOXA1 IDH1 NUFIP2 PPM1D SGTA SMAD4 UBQLN4	38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45
Entrez ID		27122	8412
HPRD ID		05659	05268
Ensembl ID		ENSG00000050165	ENSG00000137936
Uniprot IDs		F6SYF8 Q9UBP4	A0A384MTS3 B3KNL6 B3KP06 O75815
PDB IDs			3T6A
Enriched GO Terms of Interacting Partners?
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