CDC42BPA and PPP1R12C

Number of citations of the paper that reports this interaction (PubMedID 11399775)
55

Data Source:
HPRD (in vivo)

		CDC42BPA	PPP1R12C
Description		CDC42 binding protein kinase alpha	protein phosphatase 1 regulatory subunit 12C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Extracellular Exosome	Cytoplasm Cytoskeleton
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding
	Biological Process	Protein Phosphorylation Cell Migration Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Intracellular Signal Transduction	Signal Transduction Negative Regulation Of Catalytic Activity
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 28135244) Low density lipoprotein cholesterol levels ( 33339817) Macular thickness ( 30535121) Mercury levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) SAPHO syndrome ( 33816493) Smoking initiation ( 33082346) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: CDC42 CDC42BPB LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C SNAPIN TAF1	27 interacting genes: ATP6V1H ATXN7 BHLHA9 C1orf109 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 FMR1 FXR1 FXR2 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SMARCA2 SPECC1L THOC1 TSFM USHBP1
Entrez ID		8476	54776
HPRD ID		04562	11452
Ensembl ID		ENSG00000143776	ENSG00000125503
Uniprot IDs		Q5VT25	Q9BZL4
PDB IDs
Enriched GO Terms of Interacting Partners?
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