NISCH and IRS4

Number of citations of the paper that reports this interaction (PubMedID 11912194)
11

Data Source:
HPRD (in vivo)

		NISCH	IRS4
Description		nischarin	insulin receptor substrate 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Intracellular Membrane-bounded Organelle Intercellular Bridge Recycling Endosome	Cytosol Plasma Membrane
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Glucose Metabolic Process Apoptotic Process Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion	Signal Transduction Insulin Receptor Signaling Pathway
Pathways		RAC1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle	IRS-related events triggered by IGF1R
Drugs		Tizanidine Agmatine Moxonidine
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Body shape index ( 34021172) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Parkinson's disease ( 28892059) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: AR IRS4 ITGA5 OGT PTGER4 TWF2	23 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG
Entrez ID		11188	8471
HPRD ID		11391	04620
Ensembl ID		ENSG00000010322	ENSG00000133124
Uniprot IDs		Q9Y2I1	O14654
PDB IDs		3P0C
Enriched GO Terms of Interacting Partners?
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