THOC3 and MLKL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		THOC3	MLKL
Description		THO complex 3	mixed lineage kinase domain like pseudokinase
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleoplasm Nuclear Speck	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Junction
	Molecular Function	RNA Binding	Protein Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing Viral MRNA Export From Host Cell Nucleus	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS		Chronotype ( 30696823)	Testicular germ cell tumor ( 23666239)
Interacting Genes		6 interacting genes: BRCA1 DDX39B DLG4 MLKL PTEN TK1	8 interacting genes: ANAPC11 CDK1 NDUFB7 PMFBP1 PSMB1 RAD18 S100A10 THOC3
Entrez ID		84321	197259
HPRD ID		09497	08752
Ensembl ID		ENSG00000051596	ENSG00000168404
Uniprot IDs		Q96J01	Q8NB16
PDB IDs		7APK	2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1
Enriched GO Terms of Interacting Partners?
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