MLKL and S100A10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MLKL	S100A10
Description		mixed lineage kinase domain like pseudokinase	S100 calcium binding protein A10
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Junction	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Extrinsic Component Of Plasma Membrane Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome AnxA2-p11 Complex
	Molecular Function	Protein Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Transmembrane Transporter Binding Calcium-dependent Protein Binding
	Biological Process	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	Membrane Raft Assembly Vesicle Budding From Membrane Response To Xenobiotic Stimulus Positive Regulation Of GTPase Activity Positive Regulation Of Binding Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis	Dissolution of Fibrin Clot
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Testicular germ cell tumor ( 23666239)	Asthma ( 31619474) Diverticular disease ( 30177863) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 29545352) Urinary metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		8 interacting genes: ANAPC11 CDK1 NDUFB7 PMFBP1 PSMB1 RAD18 S100A10 THOC3	21 interacting genes: ANXA2 ANXA7 BAD CDK16 COPS6 CTSB ERBB3 FSHR KCNK3 MLKL NANOS2 PLA2G4C PLG S100A3 S100Z SETDB1 SUMO2 TRPV5 TRPV6 USP2 ZGPAT
Entrez ID		197259	6281
HPRD ID		08752	00232
Ensembl ID		ENSG00000168404	ENSG00000197747
Uniprot IDs		Q8NB16	P60903
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1	1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH
Enriched GO Terms of Interacting Partners?
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