MLKL and THOC3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		MLKL	THOC3
Description		mixed lineage kinase domain like pseudokinase	THO complex 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Junction	Transcription Export Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleoplasm Nuclear Speck
	Molecular Function	Protein Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein-containing Complex Binding	RNA Binding
	Biological Process	Protein Phosphorylation Cell Surface Receptor Signaling Pathway Defense Response To Virus Protein Homotrimerization Necroptotic Process Necroptotic Signaling Pathway Execution Phase Of Necroptosis	MRNA Processing MRNA Export From Nucleus RNA Splicing Viral MRNA Export From Host Cell Nucleus
Pathways		TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Microbial modulation of RIPK1-mediated regulated necrosis	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)	Chronotype ( 30696823)
Interacting Genes		8 interacting genes: ANAPC11 CDK1 NDUFB7 PMFBP1 PSMB1 RAD18 S100A10 THOC3	6 interacting genes: BRCA1 DDX39B DLG4 MLKL PTEN TK1
Entrez ID		197259	84321
HPRD ID		08752	09497
Ensembl ID		ENSG00000168404	ENSG00000051596
Uniprot IDs		Q8NB16	Q96J01
PDB IDs		2MSV 4M67 4MWI 5KNJ 5KO1 6BWK 6D74 6LK5 6LK6 6O5Z 6UX8 6ZLE 6ZPR 6ZVO 6ZZ1	7APK
Enriched GO Terms of Interacting Partners?
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