RNF135 and ENOX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RNF135	ENOX2
Description		ring finger protein 135	ecto-NOX disulfide-thiol exchanger 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding RIG-I Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleic Acid Binding Protein-disulfide Reductase Activity
	Biological Process	Protein Polyubiquitination Free Ubiquitin Chain Polymerization Protein Ubiquitination Positive Regulation Of Interferon-beta Production RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Protein Homooligomerization Protein K63-linked Ubiquitination Antiviral Innate Immune Response	Ultradian Rhythm Electron Transport Chain Regulation Of Growth
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs			Idronoxil
Diseases
GWAS		Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)	Hemoglobin ( 32888494)
Interacting Genes		10 interacting genes: CTBP2 CTNNAL1 DDX58 ENOX2 GOLGA2 HSF2BP IFIH1 TEPSIN UBE2D2 UBE2N	20 interacting genes: CDC37 CIB3 ENOX1 GORASP2 INTS4 LNX1 MAGEA11 MAGEA3 MLLT6 NDOR1 NTAQ1 RNF135 SNRPA SRPK2 STAMBPL1 TFIP11 TRAF5 TUBB4B VCL ZFP2
Entrez ID		84282	10495
HPRD ID		11506	02234
Ensembl ID		ENSG00000181481	ENSG00000165675
Uniprot IDs		B3KV69 Q8IUD6	Q16206 Q32ND0
PDB IDs		7JL1 7JL3
Enriched GO Terms of Interacting Partners?
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