RNF135

Description		ring finger protein 135
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding RIG-I Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Free Ubiquitin Chain Polymerization Protein Ubiquitination Positive Regulation Of Interferon-beta Production RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Protein Homooligomerization Protein K63-linked Ubiquitination Antiviral Innate Immune Response
Pathways		DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		10 interacting genes: CTBP2 CTNNAL1 DDX58 ENOX2 GOLGA2 HSF2BP IFIH1 TEPSIN UBE2D2 UBE2N
Entrez ID		84282
HPRD ID		11506
Ensembl ID		ENSG00000181481
Uniprot IDs		B3KV69 Q8IUD6
PDB IDs		7JL1 7JL3
Enriched GO Terms of Interacting Partners?
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