BAP1 and USP21

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		BAP1	USP21
Description		BRCA1 associated protein 1	ubiquitin specific peptidase 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PR-DUB Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Chromatin Binding Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity	Transcription Coactivator Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Response To Inorganic Substance Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Regulation Of Cell Cycle Macrophage Homeostasis Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		30 interacting genes: BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 IGF1R ITPR3 KLF5 LINC00598 MAP3K1 NBN PARP3 PLN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	61 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		8314	27005
HPRD ID		04366	05291
Ensembl ID		ENSG00000163930	ENSG00000143258
Uniprot IDs		A0A024R305 F8W6N3 Q92560	Q9UK80
PDB IDs			2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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