USP21 and SENP8

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		USP21	SENP8
Description		ubiquitin specific peptidase 21	SUMO peptidase family member, NEDD8 specific
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytosol
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated	Protein Deubiquitination Post-translational Protein Modification
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	UCH proteinases Neddylation
Drugs
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		61 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350	15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		27005	123228
HPRD ID		05291	09784
Ensembl ID		ENSG00000143258	ENSG00000166192
Uniprot IDs		Q9UK80	A8K8D3 Q96LD8
PDB IDs		2Y5B 3I3T 3MTN	1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?
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