USP9X and RPGR

		USP9X	RPGR
Description		ubiquitin specific peptidase 9 X-linked	retinitis pigmentosa GTPase regulator
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Growth Cone	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity Co-SMAD Binding Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Cell Cycle Chromosome Segregation Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Protein Localization Cell Migration Protein Ubiquitination Protein Deubiquitination BMP Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Axon Extension Protein Stabilization Cell Division Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Demethylation Amyloid Fibril Formation	Intracellular Protein Transport Visual Perception Intraciliary Transport Regulation Of Catalytic Activity Response To Stimulus Cilium Assembly
Pathways		Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes RHOU GTPase cycle RHOV GTPase cycle Peroxisomal protein import Peroxisomal protein import Amyloid fiber formation
Drugs
Diseases
GWAS		Migraine ( 27322543)
Interacting Genes		27 interacting genes: AFDN ALDH1A3 BCL9 CTNNB1 DCX DVL2 ERG FBXW7 GPSM1 MAP3K5 MCL1 NEAT1 PEX5 PSD4 PTEN RICTOR RNF115 RPGR SMAD2 SMAD4 SMN2 SMURF1 STIL SUMO2 TDRD3 UBC VHL	19 interacting genes: ATP6AP2 DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 NUDT12 PDE6D RPGRIP1 SLC25A10 SLC9A7 SMC1A SMC3 TSPAN7 TUBG1 USP9X YWHAE
Entrez ID		8239	6103
HPRD ID		02091	02425
Ensembl ID		ENSG00000124486	ENSG00000156313
Uniprot IDs		Q6P468 Q86X58 Q93008	Q92834
PDB IDs		5VBD 5WCH	4JHN 4JHP 4QAM
Enriched GO Terms of Interacting Partners?
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