DOCK8 and RTP5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		DOCK8	RTP5
Description		dedicator of cytokinesis 8	receptor transporter protein 5 (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane	Integral Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Olfactory Receptor Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Protein Targeting To Membrane Protein Insertion Into Membrane
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production	Olfactory Signaling Pathway
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		26 interacting genes: BYSL CARHSP1 CDC42 CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	51 interacting genes: ACTN2 ACTN3 AKAP8L APOC1 ASPG BEND5 BPIFA1 CALCOCO2 CARD9 CBY2 CIDEB COG6 DOCK8 EIF3F FGF14 GOLGA2 GOLGA6L9 HNRNPK HSF2BP KIFAP3 KRT27 KRT31 KRT33B KRT34 KRT40 KRT86 KRTAP19-5 KRTAP6-2 LZTS2 MDFI MIPOL1 MIS18A MKRN3 MTUS2 NFKBID PDE4DIP PNMA1 PNMA2 PSMA3 PSMA6 PSTPIP1 RBPMS RINT1 ROPN1 SERTAD3 SP100 SPDL1 TRAF1 TRIM23 TSGA10 USHBP1
Entrez ID		81704	285093
HPRD ID		10920	08159
Ensembl ID		ENSG00000107099	ENSG00000188011
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q14D33
PDB IDs
Enriched GO Terms of Interacting Partners?
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