DOCK8 and ZFC3H1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		DOCK8	ZFC3H1
Description		dedicator of cytokinesis 8	zinc finger C3H1-type containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane	Exosome (RNase Complex) Extracellular Space Nucleus Nucleolus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Metal Ion Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	RNA Processing
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		26 interacting genes: BYSL CARHSP1 CDC42 CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	19 interacting genes: CADPS CCDC57 CCDC85B CEP70 COG6 CSNK2A1 DOCK8 GOLGA2 HNRNPK HSF2BP KHDRBS2 MKRN3 MTUS2 NINL PIBF1 SPAG5 SRPK2 TRIM27 ZDHHC17
Entrez ID		81704	196441
HPRD ID		10920	14489
Ensembl ID		ENSG00000107099	ENSG00000133858
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	O60293
PDB IDs
Enriched GO Terms of Interacting Partners?
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