DOCK8 and RHOQ

Number of citations of the paper that reports this interaction (PubMedID 15304341)
37

Data Source:
HPRD (two hybrid)

		DOCK8	RHOQ
Description		dedicator of cytokinesis 8	ras homolog family member Q
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane	Actin Filament Plasma Membrane Golgi-associated Vesicle Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding Profilin Binding GTP Binding GBD Domain Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Dendritic Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	Endocytosis Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Cell Migration Cell Projection Assembly Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II GTP Metabolic Process Positive Regulation Of Glucose Import Positive Regulation Of Filopodium Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle Factors involved in megakaryocyte development and platelet production	Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases regulate CFTR trafficking RHOQ GTPase cycle
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Post bronchodilator FEV1 ( 26634245) Red cell distribution width ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		26 interacting genes: BYSL CARHSP1 CDC42 CHMP2A COG6 DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ HSF2BP KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	23 interacting genes: BANP CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DHFR DOCK8 EXOC7 GOPC MORN4 NTAQ1 PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL ZNF417
Entrez ID		81704	23433
HPRD ID		10920	05791
Ensembl ID		ENSG00000107099	ENSG00000119729
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	D6W5A7 P17081 V9HWD0
PDB IDs			2ATX
Enriched GO Terms of Interacting Partners?
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