GALNT12 and MLH3

Number of citations of the paper that reports this interaction (PubMedID 24412244)
2

Data Source:
BioGRID (two hybrid)

		GALNT12	MLH3
Description		polypeptide N-acetylgalactosaminyltransferase 12	mutL homolog 3
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex
	Molecular Function	Polypeptide N-acetylgalactosaminyltransferase Activity Carbohydrate Binding Metal Ion Binding	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Centromeric DNA Binding Mismatched DNA Binding
	Biological Process	O-glycan Processing	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization
Pathways		Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins	Meiotic recombination
Drugs
Diseases
GWAS		Asthma ( 31959851) Brain morphology (MOSTest) ( 32665545) FEV1 ( 30804560) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033) Leftâ€“right brain asymmetry ( 33723403) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824)	Inflammatory bowel disease ( 23128233) Mood instability ( 29187730) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC	48 interacting genes: AKT1 ALDOB ANP32B AOPEP AR BAAT CCDC180 CDC14B CDK8 CTSV CYLC2 DVL1 EXO1 FANCC FBP1 FBP2 FRAT2 GALNT12 HEMGN HRAS HSD17B3 IGFBP3 LEF1 MAP2K1 MLH1 MSANTD3 MSH4 MSH5 NANS PCNA PPP2CB PPP3R2 RASA1 SEC61B SFRP2 SMAD1 STX17 TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRIM55 TRIM63 TSTD2 XPA ZDHHC17 ZNF510
Entrez ID		79695	27030
HPRD ID		13561	05094
Ensembl ID		ENSG00000119514	ENSG00000119684
Uniprot IDs		Q8IXK2	Q2M1Z1 Q9UHC1
PDB IDs		6PXU
Enriched GO Terms of Interacting Partners?
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