DHRS11 and GSDMB

		DHRS11	GSDMB
Description		dehydrogenase/reductase 11	gasdermin B
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GO Annotations	Cellular Component	Cellular_component Extracellular Region	Cellular_component Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Nucleotide Binding 3-keto Sterol Reductase Activity Estradiol 17-beta-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-ketosteroid Reductase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity	Phosphatidylserine Binding Molecular_function Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Steroid Biosynthetic Process Estrogen Biosynthetic Process	Cytolysis Defense Response To Bacterium Pyroptosis
Pathways
Drugs		Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462)	Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 34103634 20860503 32296059 31619474 29273806 28461288) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 27611488 24241537 29273806) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 28314753 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 21738480)
Interacting Genes		2 interacting genes: DLG3 GSDMB	17 interacting genes: AGT APP CDK12 CLK1 CWC25 DHRS11 FNDC8 GGNBP2 HIVEP1 IGFBP2 MRM1 MYO19 NLE1 ORM1 PEBP1 SERPINA1 SLFN12
Entrez ID		79154	55876
HPRD ID		08331	17082
Ensembl ID		ENSG00000278535	ENSG00000073605
Uniprot IDs		A0A024R0T1 Q6UWP2	Q8TAX9
PDB IDs		1XG5	5TIB 5TJ2 5TJ4
Enriched GO Terms of Interacting Partners?
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