GSDMB and DHRS11

		GSDMB	DHRS11
Description		gasdermin B	dehydrogenase/reductase 11
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GO Annotations	Cellular Component	Cellular_component Cytoplasm Plasma Membrane Integral Component Of Membrane	Cellular_component Extracellular Region
	Molecular Function	Phosphatidylserine Binding Molecular_function Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Nucleotide Binding 3-keto Sterol Reductase Activity Estradiol 17-beta-dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-ketosteroid Reductase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Cytolysis Defense Response To Bacterium Pyroptosis	Steroid Biosynthetic Process Estrogen Biosynthetic Process
Pathways
Drugs			Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 34103634 20860503 32296059 31619474 29273806 28461288) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 27611488 24241537 29273806) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 28314753 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 21738480)	Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462)
Interacting Genes		17 interacting genes: AGT APP CDK12 CLK1 CWC25 DHRS11 FNDC8 GGNBP2 HIVEP1 IGFBP2 MRM1 MYO19 NLE1 ORM1 PEBP1 SERPINA1 SLFN12	2 interacting genes: DLG3 GSDMB
Entrez ID		55876	79154
HPRD ID		17082	08331
Ensembl ID		ENSG00000073605	ENSG00000278535
Uniprot IDs		Q8TAX9	A0A024R0T1 Q6UWP2
PDB IDs		5TIB 5TJ2 5TJ4	1XG5
Enriched GO Terms of Interacting Partners?
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