GSDMB and IGFBP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		GSDMB	IGFBP2
Description		gasdermin B	insulin like growth factor binding protein 2
Image
GO Annotations	Cellular Component	Cellular_component Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Apical Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Molecular_function Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding
	Biological Process	Cytolysis Defense Response To Bacterium Pyroptosis	Signal Transduction Female Pregnancy Aging Response To Nutrient Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Lithium Ion Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Regulation Of Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Adult asthma ( 30787307) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 21804549 31361310 31959851 30929738 34103634 20860503 32296059 31619474 29273806 28461288) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 27611488 24241537 29273806) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Bronchial hyperresponsiveness in asthma ( 27439200) Cervical cancer ( 23817570) Childhood asthma with severe exacerbations ( 33328473) Crohn's disease ( 28067908) Dermatomyositis or juvenile dermatomyositis ( 26362759) Feeling miserable ( 29500382) Fractional exhaled nitric oxide (childhood) ( 24315451) IgM levels ( 28628107) Inflammatory bowel disease ( 28067908 23128233) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Monocyte percentage of white cells ( 27863252) Primary biliary cholangitis ( 23000144 20639880 30643196) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33339817) Subcutaneous adipose tissue ( 27918534) Systemic lupus erythematosus ( 26502338) Systemic sclerosis ( 28314753 31672989) Type 1 diabetes ( 30659077 25751624) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 21738480)	Glomerular filtration rate (creatinine) ( 28452372) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) Mitral valve prolapse ( 26301497) Thyroid stimulating hormone levels ( 25743335) Type 2 diabetes ( 26818947)
Interacting Genes		17 interacting genes: AGT APP CDK12 CLK1 CWC25 DHRS11 FNDC8 GGNBP2 HIVEP1 IGFBP2 MRM1 MYO19 NLE1 ORM1 PEBP1 SERPINA1 SLFN12	9 interacting genes: BMPR2 CASP10 GSDMB IGF1 IGF2 INO80B KLK2 RPS6KA1 TF
Entrez ID		55876	3485
HPRD ID		17082	00898
Ensembl ID		ENSG00000073605	ENSG00000115457
Uniprot IDs		Q8TAX9	C9JMY1 P18065
PDB IDs		5TIB 5TJ2 5TJ4	2H7T
Enriched GO Terms of Interacting Partners?
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