LAPTM5 and GYPA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LAPTM5	GYPA
Description		lysosomal protein transmembrane 5	glycophorin A (MNS blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Integral Component Of Plasma Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-dependent Protein Binding Protein Sequestering Activity	Virus Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Defense Response To Tumor Cell Positive Regulation Of Cytokine Production Involved In Immune Response Protein Targeting To Lysosome Intracellular Protein Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Induction Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of MAPK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of Macrophage Cytokine Production Golgi To Lysosome Transport Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Autophagic Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor Catabolic Process	Viral Entry Into Host Cell
Pathways			Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Adult body size ( 32376654) Bipolar disorder (body mass index interaction) ( 24322204) Blood pressure (smoking interaction) ( 25189868) Chronic obstructive pulmonary disease ( 30804561 25101718) Diabetic neuropathy in type 2 diabetes ( 33430853) Diastolic blood pressure ( 27841878) Femoral neck bone mineral density ( 30172743) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lung function (low FEV1 vs high FEV1) ( 26423011) Major depressive disorder x sex interaction ( 34099189) Malaria ( 31844061) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Recurrent major depressive disorder x sex interaction ( 34099189) Red blood cell count ( 29403010) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Severe malaria ( 26416757) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 32888494)
Interacting Genes		39 interacting genes: AIG1 ANKRD13A C4orf3 CLDN19 CYB5R3 DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 GYPA HERC1 HEY1 HEYL HMOX2 HUWE1 INSIG2 ITCH KIR3DL3 KRT7 LDLRAD1 MRPL18 NEDD4 NEDD4L RNF168 RPRM RTP2 SLC22A2 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC UBE2J1 USP13 VAMP1 WWP1	25 interacting genes: ANKRD29 CLDN5 CREB3 CUL3 ELOVL4 ERGIC3 EVA1A FAM209A FFAR2 GOLT1A GPRC5D GPX8 KEAP1 LAPTM5 PDZK1IP1 SAR1A SGTA SGTB SLC10A6 TLCD4 TMBIM6 TMEM14B TMEM154 TMEM237 TMEM31
Entrez ID		7805	2993
HPRD ID		03280	07508
Ensembl ID		ENSG00000162511	ENSG00000170180
Uniprot IDs		Q13571 Q5TBB8	A0A0C4DFT7 A0A2R8Y7F9 E9PD10 P02724 Q14419
PDB IDs			1AFO 1MSR 2KPE 2KPF 5EH4 5EH6
Enriched GO Terms of Interacting Partners?
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