GET1 and PDXK

		GET1	PDXK
Description		guided entry of tail-anchored proteins factor 1	pyridoxal kinase
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane GET Complex	Extracellular Region Nucleus Nucleoplasm Cytosol Secretory Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Magnesium Ion Binding ATP Binding Zinc Ion Binding Pyridoxal Kinase Activity Pyridoxal Phosphate Binding Potassium Ion Binding Sodium Ion Binding Lithium Ion Binding Protein Homodimerization Activity
	Biological Process	Protein Insertion Into ER Membrane Protein Stabilization Tail-anchored Membrane Protein Insertion Into ER Membrane	Pyridoxal 5'-phosphate Salvage Phosphorylation
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Neutrophil degranulation Vitamins B6 activation to pyridoxal phosphate
Drugs			Pyridoxal Pyridoxine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate O6-(R)-ROSCOVITINE, R-2-(6-BENZYLOXY-9-ISOPROPYL-9H-PURIN-2-YLAMINO)-BUTAN-1-OL (2R)-2-({6-[benzyl(methyl)amino]-9-isopropyl-9H-purin-2-yl}amino)butan-1-ol
Diseases
GWAS			Blood protein levels ( 30072576) Refractive error ( 32231278) Systolic blood pressure change trajectory ( 27980656)
Interacting Genes		34 interacting genes: ABHD5 APOA2 APOL2 AQP1 BOC CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 GATD3 HMOX2 HTATIP2 ORMDL3 PDXK PLPP4 PTPN9 RASGRP3 RTP2 SCN3A SERP2 SLC35E3 SLC4A2 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42 TRAPPC10	4 interacting genes: BARD1 GET1 RIPK1 YWHAQ
Entrez ID		7485	8566
HPRD ID		04224	01526
Ensembl ID		ENSG00000182093	ENSG00000160209
Uniprot IDs		O00258	F2Z2Y4 O00764 V9HWC3
PDB IDs		6SO5	2AJP 2F7K 2YXT 2YXU 3FHX 3FHY 3KEU 4EN4 4EOH
Enriched GO Terms of Interacting Partners?
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