TSC1 and CCND2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TSC1	CCND2
Description		TSC complex subunit 1	cyclin D2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane Cyclin D2-CDK4 Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs	Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS		Migraine without aura ( 23793025) Psoriasis ( 19169254)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 30529582 26151821 24836286 31826910 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28552196 28270201) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 32203549 32154731 31928498) Type 2 diabetes ( 22885922 30054458 29358691 30297969 31118516 32499647 28869590) Waist circumference ( 31928498)
Interacting Genes		179 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 BRD3 C1orf94 CALCOCO2 CAPZA2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FCN1 FGFR4 FOLR2 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NDUFA9 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PAEP PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PPP1R32 PRMT6 PTPA RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SLC16A6 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRAF2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 TUBB4B VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765 ZNF79	67 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARID5B ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD27 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAD1L1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2
Entrez ID		7248	894
HPRD ID		05594	00451
Ensembl ID		ENSG00000165699	ENSG00000118971
Uniprot IDs		A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2	P30279
PDB IDs		4Z6Y 5EJC 7DL2	6EI2
Enriched GO Terms of Interacting Partners?
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