CCND2 and RB1

Number of citations of the paper that reports this interaction (PubMedID 9003781)
189

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, enzymatic study)
HPRD (in vitro, in vivo)

		CCND2	RB1
Description		cyclin D2	RB transcriptional corepressor 1
Image
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane Cyclin D2-CDK4 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Spindle Cytosol SWI/SNF Complex PML Body Rb-E2F Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Importin-alpha Family Protein Binding Disordered Domain Specific Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Long-term Memory Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Cellular Response To X-ray Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Tissue Homeostasis Aortic Valve Morphogenesis Chromatin Remodeling Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Sister Chromatid Biorientation Neuron Projection Development Maintenance Of Mitotic Sister Chromatid Cohesion Glial Cell Apoptotic Process Skeletal Muscle Cell Differentiation Neuron Maturation Enucleate Erythrocyte Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Lipid Kinase Activity Myoblast Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Striated Muscle Cell Differentiation Cell Division Neuron Apoptotic Process Regulation Of Cell Cycle Protein Localization To Chromosome, Centromeric Region Cellular Response To Xenobiotic Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cohesin Loading Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Centromere Complex Assembly Hepatocyte Apoptotic Process Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Inhibition of replication initiation of damaged DNA by RB1/E2F1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry RUNX2 regulates osteoblast differentiation Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Defective translocation of RB1 mutants to the nucleus Replication of the SARS-CoV-1 genome Aberrant regulation of mitotic exit in cancer due to RB1 defects Replication of the SARS-CoV-2 genome
Drugs			Insulin human Insulin pork
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 30529582 26151821 24836286 31826910 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28552196 28270201) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 32203549 32154731 31928498) Type 2 diabetes ( 22885922 30054458 29358691 30297969 31118516 32499647 28869590) Waist circumference ( 31928498)	Birth weight ( 31043758 27680694) Chronic kidney disease ( 26420894) Diastolic blood pressure ( 34074324) Lymphocyte counts ( 32888494) Offspring birth weight ( 31043758) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		67 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARID5B ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD27 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAD1L1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2	199 interacting genes: AATF ABL1 AHR ANKS1A AR ARID3B ATF2 BAAT BAG1 BDP1 BNC2 BRCA1 BRF1 CASP10 CASP2 CASP3 CASP6 CASP7 CASP8 CASP9 CBX1 CBX4 CCDC180 CCNA1 CCNA2 CCNB1 CCNC CCND1 CCND2 CCND3 CCNE1 CCNT2 CDADC1 CDC27 CDK1 CDK14 CDK2 CDK3 CDK4 CDK5 CDK6 CDK9 CDKN1A CDKN1C CEBPA CEBPB CEBPD CEBPE CHEK1 CHN2 CLNK CNTN3 CORO2A COX17 CREG1 CRYBA4 CSK CTBP1 CTSV CUX1 DGKZ DNMT1 DVL1 DYRK1A E2F1 E2F2 E2F3 E2F4 E4F1 EID1 ELF1 ENC1 EP300 ESD FANCC FBP1 FBP2 FOS FRK GALNT12 GTF3C2 HBP1 HDAC1 HDAC3 HIF1A HMGA2 HMGB1 HSPA8 ID2 INS IRF3 JUN KAT2B KAT5 KDM4A KDM5A KDM5B KMT5C L3MBTL1 LEF1 LIN54 LIN9 LMNA LRCH1 MAPK1 MAPK14 MAPK3 MAPK9 MCM7 MDM2 MDM4 MNAT1 MNDA MORF4L1 MORF4L2 MRPS18B MTRF1 MYC MYOD1 NCOA6 NDC80 NEFM ORC1 PA2G4 PAX2 PAX5 PAX6 PCDHB5 PELP1 PHB PIK3R1 PIK3R3 PLA2G12A PML POLA1 PPARG PPIA PPP1CA PPP1CB PPP1CC PPP1R26 PRDM2 PRKCB PRKRA PRMT2 PSMD10 PURA RABGAP1L RACK1 RAF1 RASA1 RBAK RBBP4 RBBP5 RBBP6 RBBP7 RBBP8 RBBP9 RING1 RINT1 RNF123 RNF40 RUNX2 SERPINB2 SHC1 SKP2 SMARCA4 SMARCB1 SMYD2 SNAPC1 SNAPC3 SNW1 SP1 SP3 SPI1 SPIB STAT3 STX17 SUV39H1 TAF1 TASOR TBP TFAP2A TGM2 THOC1 TMPO TOP2A TP53 TRAP1 TRIM27 TRIP11 TRMO UBE2I UBTF USP4 USP7 VDR XPA ZBTB16
Entrez ID		894	5925
HPRD ID		00451	01574
Ensembl ID		ENSG00000118971	ENSG00000139687
Uniprot IDs		P30279	A0A024RDV3 P06400
PDB IDs		6EI2	1AD6 1GH6 1GUX 1H25 1N4M 1O9K 1PJM 2AZE 2QDJ 2R7G 3N5U 3POM 4CRI 4ELJ 4ELL
Enriched GO Terms of Interacting Partners?
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