TRPM2 and EFHC1

Number of citations of the paper that reports this interaction (PubMedID 22226147)
12

Data Source:
BioGRID (pull down)

		TRPM2	EFHC1
Description		transient receptor potential cation channel subfamily M member 2	EF-hand domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Neuron Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Spindle Pole Centrosome Axoneme Neuronal Cell Body Mitotic Spindle
	Molecular Function	Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity Calcium Ion Binding Calcium-release Channel Activity Hydrolase Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity	Calcium Ion Binding Protein Binding Protein C-terminus Binding Alpha-tubulin Binding
	Biological Process	Temperature Homeostasis Dendritic Cell Chemotaxis Calcium Ion Transport Response To Heat Response To Purine-containing Compound Positive Regulation Of Insulin Secretion Response To Hydroperoxide Calcium-mediated Signaling Using Intracellular Calcium Source Sodium Ion Transmembrane Transport Estrous Cycle Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Purine-containing Compound Manganese Ion Transmembrane Transport Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Actin Cytoskeleton Reorganization	Mitotic Cytokinesis Mitotic Spindle Organization Cerebral Cortex Cell Migration Regulation Of Cell Division Cilium-dependent Cell Motility
Pathways		TRP channels Neutrophil degranulation
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)	Atopic march ( 26542096) Clozapine-induced myocarditis in schizophrenia ( 32066683) Mean platelet volume ( 27863252) Perceived intensity of glucose ( 31005972) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: EFHC1 ITPR3 TRAPPC10 TRPC6	67 interacting genes: C11orf45 C20orf85 CACNA1E CALCOCO2 CFAP161 CHCHD3 DOK7 EFHC2 EIF4ENIF1 FMR1 GADD45B GAS2L2 GOLGA2 HOMER3 IHO1 IKZF3 IMP3 ITGB3BP KCTD4 KRT15 KRT18 KRT75 LMO2 LRRC61 MAMDC2 MBD3L1 METTL27 MIIP MRNIP MTFR1L NQO2 NRIP3 NUP54 OIP5 PAX6 PBX1 PBX2 PMF1 PRR5L RCN1 REL RIMBP3 RNF125 SAPCD1 SELENOV SH3GLB2 SLAIN1 SNAI1 SORBS3 SPATA2 SYNGAP1 TCF4 TEKT1 TEX11 TLE5 TP53BP2 TRAF2 TRIP6 TRPM2 TSGA10IP TTC23L UBAP2 VBP1 WASF1 WHRN YJU2B ZBED1
Entrez ID		7226	114327
HPRD ID		04777	10583
Ensembl ID		ENSG00000142185	ENSG00000096093
Uniprot IDs		B4DVI8 O94759 Q14DR2	B2CKC5 Q5JVL4
PDB IDs		6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU
Enriched GO Terms of Interacting Partners?
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