TPM2 and PDLIM7

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		TPM2	PDLIM7
Description		tropomyosin 2	PDZ and LIM domain 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Actin Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Muscle Contraction Actin Filament Organization Regulation Of ATPase Activity	Ossification Receptor-mediated Endocytosis Heart Development Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Osteoblast Differentiation Muscle Structure Development
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	RET signaling
Drugs
Diseases
GWAS		Immature fraction of reticulocytes ( 32888494) Platelet count ( 32888494) White blood cell count ( 32888494)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ABI2 ACTA1 ACTB FARS2 GRK2 JUN MAST2 MESD MRFAP1 NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL SNAPIN TFPT TPM1 ZNF229 ZNF620 ZNF785	63 interacting genes: ABI2 AP5B1 BAG3 BSG CATSPER1 CCDC185 CDK12 DDX6 DGCR6 DNER ENKD1 FAM214B FAM71C FAM90A1 FNDC11 FRS3 GEM GFAP GPATCH2L HEY2 HNRNPD HNRNPF HSF2BP HSPB7 IL16 IQGAP1 KANK2 MDM2 NUDT10 OTUD6A PAK5 PARVG PCBP1 PHF1 PIN1 PLEKHN1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RASGEF1B RET RPP25 SCNM1 SH2B2 SH3BP2 SLAIN1 SMURF1 SPP1 TCF19 TNPO2 TP53 TPM2 TRAF2 TRAF3 TSG101 TSGA10IP UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		7169	9260
HPRD ID		11768	10436
Ensembl ID		ENSG00000198467	ENSG00000196923
Uniprot IDs		A7XZE4 P07951 Q5TCU3 V9HW25	Q9NR12
PDB IDs			2Q3G
Enriched GO Terms of Interacting Partners?
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