PDLIM7 and RASGEF1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PDLIM7	RASGEF1B
Description		PDZ and LIM domain 7	RasGEF domain family member 1B
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin	Early Endosome Late Endosome Midbody
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Ossification Receptor-mediated Endocytosis Heart Development Actin Cytoskeleton Organization Cell Differentiation Positive Regulation Of Osteoblast Differentiation Muscle Structure Development	Small GTPase Mediated Signal Transduction Regulation Of Catalytic Activity
Pathways		RET signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 28552196) Cocaine dependence ( 31212010) Coronary artery disease ( 32469254 33020668) Depression in smokers ( 30219690) Diffusing capacity of carbon monoxide ( 30694715) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 25429064 31562340 18391951) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 23377640) Myocardial infarction ( 33532862) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Plasma parathyroid hormone levels ( 30134803) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Response to antidepressants in depression ( 29998114) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 34021172) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		63 interacting genes: ABI2 AP5B1 BAG3 BSG CATSPER1 CCDC185 CDK12 DDX6 DGCR6 DNER ENKD1 FAM214B FAM71C FAM90A1 FNDC11 FRS3 GEM GFAP GPATCH2L HEY2 HNRNPD HNRNPF HSF2BP HSPB7 IL16 IQGAP1 KANK2 MDM2 NUDT10 OTUD6A PAK5 PARVG PCBP1 PHF1 PIN1 PLEKHN1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RASGEF1B RET RPP25 SCNM1 SH2B2 SH3BP2 SLAIN1 SMURF1 SPP1 TCF19 TNPO2 TP53 TPM2 TRAF2 TRAF3 TSG101 TSGA10IP UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	4 interacting genes: BAZ2B PDLIM7 PLEKHF2 TSGA10IP
Entrez ID		9260	153020
HPRD ID		10436	17955
Ensembl ID		ENSG00000196923	ENSG00000138670
Uniprot IDs		Q9NR12	Q0VAM2
PDB IDs		2Q3G
Enriched GO Terms of Interacting Partners?
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