TP53BP1 and SLC6A9

		TP53BP1	SLC6A9
Description		tumor protein p53 binding protein 1	solute carrier family 6 member 9
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex	Endosome Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Integral Component Of Synaptic Vesicle Membrane Dense Core Granule Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	P53 Binding Damaged DNA Binding Transcription Coregulator Activity Protein Binding Methylated Histone Binding Telomeric DNA Binding Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Modification-dependent Histone Binding	Glycine Transmembrane Transporter Activity Glycine:sodium Symporter Activity
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Protein Homooligomerization Cellular Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Neurotransmitter Transport Glycine Transport Sodium Ion Transmembrane Transport Positive Regulation Of Hemoglobin Biosynthetic Process Positive Regulation Of Heme Biosynthetic Process Transport Across Blood-brain Barrier Glycine Import Across Plasma Membrane Positive Regulation Of Iron Ion Transmembrane Transporter Activity Positive Regulation Of Iron Ion Import Across Plasma Membrane Negative Regulation Of NMDA Glutamate Receptor Activity
Pathways		SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Na+/Cl- dependent neurotransmitter transporters
Drugs
Diseases
GWAS		Antibody level in response to infection ( 25758998) Apolipoprotein A1 levels ( 32203549) Cardiometabolic and hematological traits ( 27668658) Eosinophil counts ( 32888494) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Liver volume ( 34128465) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 27036123)	Attention deficit hyperactivity disorder or cannabis use ( 30610198) Autism spectrum disorder or schizophrenia ( 28540026) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 29403010 32888494) Refractive error ( 32231278)
Interacting Genes		59 interacting genes: ANKS1A ARAP1 ATM BCL6 BLM BRCA1 BRCA2 C10orf55 CCDC120 CCNB1 CDK1 CHEK1 CRB2 CREB5 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AC4 H2AX H4-16 H4C1 H4C14 HGS IFI16 KAT8 KDM1A KLHDC7B LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16 OXER1 PARP1 PAXIP1 PCNT PITX1 POU6F2 PTEN RAD18 RAD50 RAD51 RBL1 RBL2 RELA SLC6A9 SPAG9 SUMO2 TFDP1 TLX3 TP53 UBAP2 USP28 VAC14	6 interacting genes: GABRR1 NAPA PPP2R3B PRKCA STX1A TP53BP1
Entrez ID		7158	6536
HPRD ID		05569	03010
Ensembl ID		ENSG00000067369	ENSG00000196517
Uniprot IDs		A6NNK5 Q12888	B7Z3W8 B7Z589 P48067
PDB IDs		1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT 6VA5 6VIP
Enriched GO Terms of Interacting Partners?
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