TRAPPC10 and TRPM2

		TRAPPC10	TRPM2
Description		trafficking protein particle complex subunit 10	transient receptor potential cation channel subfamily M member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol TRAPP Complex TRAPPII Protein Complex	Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane Specific Granule Membrane Neuron Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity Calcium Ion Binding Calcium-release Channel Activity Hydrolase Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity
	Biological Process	Intra-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport	Temperature Homeostasis Dendritic Cell Chemotaxis Calcium Ion Transport Response To Heat Response To Purine-containing Compound Positive Regulation Of Insulin Secretion Response To Hydroperoxide Calcium-mediated Signaling Using Intracellular Calcium Source Sodium Ion Transmembrane Transport Estrous Cycle Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Purine-containing Compound Manganese Ion Transmembrane Transport Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Cation Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Actin Cytoskeleton Reorganization
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	TRP channels Neutrophil degranulation
Drugs
Diseases
GWAS			Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Interacting Genes		15 interacting genes: GET1 SLC19A1 SUMO3 TFF1 TFF2 TFF3 TMPRSS2 TRAPPC12 TRAPPC3L TRAPPC6A TRAPPC6B TRAPPC8 TRPM2 U2AF1 UBE2G2	4 interacting genes: EFHC1 ITPR3 TRAPPC10 TRPC6
Entrez ID		7109	7226
HPRD ID		03656	04777
Ensembl ID		ENSG00000160218	ENSG00000142185
Uniprot IDs		P48553	B4DVI8 O94759 Q14DR2
PDB IDs			6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU
Enriched GO Terms of Interacting Partners?
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