TESK1 and PFKL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TESK1	PFKL
Description		testis associated actin remodelling kinase 1	phosphofructokinase, liver type
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Lamellipodium Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol 6-phosphofructokinase Complex Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity	6-phosphofructokinase Activity Protein Binding ATP Binding AMP Binding Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Negative Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly	Fructose 6-phosphate Metabolic Process Glycolytic Process Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Insulin Secretion Canonical Glycolysis
Pathways		Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Neutrophil degranulation Glycolysis
Drugs		Fostamatinib
Diseases
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Rheumatoid arthritis ( 21505073)
Interacting Genes		8 interacting genes: ABCB4 ARAF CFL1 IL17RA PFKL SPRY4 YWHAB YY1	16 interacting genes: APP ATN1 COPS6 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PCNT PFKM PRPF40A SHANK3 SUMO2 TESK1 TNFAIP3 YWHAQ
Entrez ID		7016	5211
HPRD ID		03470	01385
Ensembl ID		ENSG00000107140	ENSG00000141959
Uniprot IDs		Q15569 Q8NFJ4	P17858 Q7L2M7
PDB IDs
Enriched GO Terms of Interacting Partners?
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