SVIL and P2RX7

Number of citations of the paper that reports this interaction (PubMedID 11707406)
126

Data Source:
HPRD (in vivo)

		SVIL	P2RX7
Description		supervillin	purinergic receptor P2X 7
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Bleb Postsynapse
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping	Regulation Of Sodium Ion Transport Response To Ischemia Cell Surface Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Interleukin-1 Beta Production Response To ATP Positive Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Purinergic Nucleotide Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Pore Complex Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To ATP Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Bleb Assembly Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling
Pathways			Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs			Promethazine
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)	Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Interacting Genes		36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A SLAMF7 STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG	20 interacting genes: ACTB CASK CSF2 CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 PTPN11 SVIL TM9SF1 TRIM27 ZNF655
Entrez ID		6840	5027
HPRD ID		04992	03977
Ensembl ID		ENSG00000197321	ENSG00000089041
Uniprot IDs		A0A6I8PIX7 O95425 Q569J5	Q99572
PDB IDs		2K6M 2K6N
Enriched GO Terms of Interacting Partners?
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