AURKC and CENPA

Number of citations of the paper that reports this interaction (PubMedID 20663916)
39

Data Source:
BioGRID (enzymatic study)

		AURKC	CENPA
Description		aurora kinase C	centromere protein A
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Nucleus Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Nucleosome Inner Kinetochore Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Protein Serine Kinase Activity	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Mitotic Spindle Organization Spermatogenesis Attachment Of Spindle Microtubules To Kinetochore Histone Modification Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Oocyte Development Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		SNS-314 Fostamatinib
Diseases
GWAS			Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2	11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2
Entrez ID		6795	1058
HPRD ID		04605	00313
Ensembl ID		ENSG00000105146	ENSG00000115163
Uniprot IDs		Q9UQB9	P49450
PDB IDs		6GR8 6GR9	3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM 7D20
Enriched GO Terms of Interacting Partners?
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