AURKC and TACC2

Number of citations of the paper that reports this interaction (PubMedID 14602875)
13

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AURKC	TACC2
Description		aurora kinase C	transforming acidic coiled-coil containing protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Nucleus Cytoplasm Spindle Spindle Microtubule Midbody Spindle Pole Centrosome Chromosome Passenger Complex Spindle Midzone	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Protein Serine Kinase Activity	Nuclear Receptor Binding
	Biological Process	Protein Phosphorylation Mitotic Spindle Organization Spermatogenesis Attachment Of Spindle Microtubules To Kinetochore Histone Modification Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Histone-serine Phosphorylation Oocyte Development Mitotic Spindle Midzone Assembly Cell Division Meiotic Cell Cycle	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Cell Population Proliferation Cerebral Cortex Development
Pathways
Drugs		SNS-314 Fostamatinib
Diseases
GWAS			Chronic lymphocytic leukemia (time to first treatment) ( 33510140) Hepcidin/ferritin ratio ( 27846281) Metabolite risk score for predicting weight gain ( 31560688) Myopia (pathological) ( 23049088) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Obesity-related traits ( 23251661) Opioid dependence ( 31250797) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Total body bone mineral density ( 29304378)
Interacting Genes		13 interacting genes: BIRC5 BIRC7 BRCA1 CADPS CENPA H3C1 INCENP LNX1 NEDD4 NEDD4L OTX2 SRPK1 TACC2	18 interacting genes: AURKC BORCS6 CLK2 CLVS2 CREBBP EP300 FMR1 FXR1 GRAMD4 HMG20B KAT2A KAT2B PPP1CC RXRB SMARCA2 SMARCB1 TGM1 YEATS4
Entrez ID		6795	10579
HPRD ID		04605	05600
Ensembl ID		ENSG00000105146	ENSG00000138162
Uniprot IDs		Q9UQB9	B2RWP4 B7ZMJ9 D6RAA5 O95359 Q4VXL4 Q4VXL8
PDB IDs		6GR8 6GR9
Enriched GO Terms of Interacting Partners?
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