SLC1A6 and ARIH2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLC1A6	ARIH2
Description		solute carrier family 1 member 6	ariadne RBR E3 ubiquitin protein ligase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Intermediate Filament Cytoskeleton Synapse Membrane Protein Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	High-affinity Glutamate Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Neurotransmitter Uptake Ion Transport Neurotransmitter Transport Chemical Synaptic Transmission Aspartate Transmembrane Transport L-glutamate Transmembrane Transport L-aspartate Transmembrane Transport L-glutamate Import Across Plasma Membrane	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Glutamate Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Glutamic acid
Diseases
GWAS		Familial squamous cell lung carcinoma ( 29924316)	Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: ARHGEF11 ARIH2	53 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R ITIH1 KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN REL RHEB RHOA RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91
Entrez ID		6511	10425
HPRD ID		09005	09286
Ensembl ID		ENSG00000105143	ENSG00000177479
Uniprot IDs		B7Z7Q5 P48664	O95376 Q53ET9 Q6IBL8
PDB IDs
Enriched GO Terms of Interacting Partners?
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