ARIH2 and ARAP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARIH2	ARAP1
Description		ariadne RBR E3 ubiquitin protein ligase 2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cytoplasmic Vesicle Golgi Cisterna Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Positive Regulation Of Receptor Recycling Signal Transduction Regulation Of Cell Shape Actin Filament Reorganization Involved In Cell Cycle Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 28892062 25673413) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Fasting blood glucose ( 25631608 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 33402679 34059833) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 30297969 26818947 32499647 30718926 28869590) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		53 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R ITIH1 KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN REL RHEB RHOA RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91	14 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6
Entrez ID		10425	116985
HPRD ID		09286	09440
Ensembl ID		ENSG00000177479	ENSG00000186635
Uniprot IDs		O95376 Q53ET9 Q6IBL8	Q96P48
PDB IDs			4X1V
Enriched GO Terms of Interacting Partners?
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