ARIH2 and RPL8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		ARIH2	RPL8
Description		ariadne RBR E3 ubiquitin protein ligase 2	ribosomal protein L8
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm	Cytosol Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Polysomal Ribosome Postsynapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding RRNA Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Cell Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Hematopoietic Stem Cell Proliferation Positive Regulation Of Protein Targeting To Mitochondrion	Cytoplasmic Translation Translation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases
GWAS		Blood protein levels ( 28240269) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Hip circumference ( 28552196) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Ulcerative colitis ( 28067908)	Blood metabolite levels ( 26401656) Logical memory (immediate recall) in normal cognition ( 29274321)
Interacting Genes		53 interacting genes: APOBEC3F APOBEC3G ARAP1 BUB1 CBR3 CCDC33 CEP126 CKB CRX DCUN1D1 DISC1 DLST EEF1A1 EEF1G EML4 ENSA IL4R ITIH1 KAT5 KCNQ2 MEOX2 NEDD8 OGT PAX6 PHF7 PPP2R1A PTN REL RHEB RHOA RPL8 SCAMP2 SGCE SLC1A6 TP53 TRIM27 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2T UBE2V1 UGP2 UTP14A WDR91	16 interacting genes: ARIH2 ARL15 C11orf49 CHDH DPH3 DUSP23 DUX4 FGFR3 FOXH1 IL7R MINDY3 NUDT3 OGT ST3GAL3 UBE2I UPF2
Entrez ID		10425	6132
HPRD ID		09286	16044
Ensembl ID		ENSG00000177479	ENSG00000161016
Uniprot IDs		O95376 Q53ET9 Q6IBL8	P62917
PDB IDs			4CCM 4CCN 4CCO 4UG0 4V6X 4Y3O 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP
Enriched GO Terms of Interacting Partners?
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