SDC2 and CYP2C18

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SDC2	CYP2C18
Description		syndecan 2	cytochrome P450 family 2 subfamily C member 18
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Retinoic Acid 4-hydroxylase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Heme Binding Aromatase Activity
	Biological Process	Biological_process Cell Migration Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis	Organic Acid Metabolic Process Xenobiotic Metabolic Process Epoxygenase P450 Pathway Xenobiotic Catabolic Process Retinol Metabolic Process Retinoic Acid Metabolic Process
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport	Xenobiotics
Drugs		Sargramostim	N,4-Dimethyl-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Diseases
GWAS		Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)	Acenocoumarol maintenance dosage ( 19578179) Clopidogrel active metabolite levels ( 28207573) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to clopidogrel therapy ( 28207573 19706858) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 23093944) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose ( 23755828) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		28 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4	6 interacting genes: A2M APOE ECSIT KMT2E PSEN1 SDC2
Entrez ID		6383	1562
HPRD ID		00803	03085
Ensembl ID		ENSG00000169439	ENSG00000108242
Uniprot IDs		A0A024R9D1 E9PBI9 P34741	P33260 Q7Z348
PDB IDs		6ITH	2CIK 2H6P
Enriched GO Terms of Interacting Partners?
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