SDC2 and LAMA3

Number of citations of the paper that reports this interaction (PubMedID 11373281)
23

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		SDC2	LAMA3
Description		syndecan 2	laminin subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Basement Membrane Laminin-5 Complex Endoplasmic Reticulum Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding Identical Protein Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent
	Biological Process	Biological_process Cell Migration Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis	Morphogenesis Of A Polarized Epithelium Integrin-mediated Signaling Pathway Axon Guidance Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Regulation Of Cell Adhesion Regulation Of Cell Migration Endodermal Cell Differentiation Regulation Of Embryonic Development Cell-cell Adhesion
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs		Sargramostim	Lanoteplase
Diseases
GWAS		Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)	Allergic rhinitis ( 25085501) Amyotrophic lateral sclerosis ( 22959728) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		28 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4	7 interacting genes: APC BMP1 LAMB3 PLAT PLG SDC2 SLC35E1
Entrez ID		6383	3909
HPRD ID		00803	02883
Ensembl ID		ENSG00000169439	ENSG00000053747
Uniprot IDs		A0A024R9D1 E9PBI9 P34741	A0A0A0MSA0 A0A0A0MTS5 A0A0A6YYF2 Q16787
PDB IDs		6ITH
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?