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CCL4 and CCL3
Number of citations of the paper that reports this interaction (PubMedID
11278300
)
21
Data Source:
HPRD
(in vivo)
CCL4
CCL3
Description
C-C motif chemokine ligand 4
C-C motif chemokine ligand 3
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Molecular Function
Cytokine Activity
Protein Binding
Chemokine Activity
CCR1 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Identical Protein Binding
CCR Chemokine Receptor Binding
Protein Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
Chemokine Activity
Phospholipase Activator Activity
Kinase Activity
CCR1 Chemokine Receptor Binding
CCR5 Chemokine Receptor Binding
Chemoattractant Activity
Identical Protein Binding
CCR Chemokine Receptor Binding
Biological Process
Monocyte Chemotaxis
Inflammatory Response
Immune Response
Cell Adhesion
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Response To Virus
Response To Toxic Substance
Neutrophil Chemotaxis
Positive Regulation Of GTPase Activity
Negative Regulation By Host Of Viral Transcription
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Calcium Ion Transport
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Natural Killer Cell Chemotaxis
MAPK Cascade
Osteoblast Differentiation
Cell Activation
Monocyte Chemotaxis
Protein Phosphorylation
Calcium Ion Transport
Cellular Calcium Ion Homeostasis
Exocytosis
Chemotaxis
Inflammatory Response
Cytoskeleton Organization
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Regulation Of Cell Shape
Response To Toxic Substance
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
T Cell Chemotaxis
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Calcium-mediated Signaling
Signaling
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Neutrophil Chemotaxis
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Eosinophil Degranulation
Protein Kinase B Signaling
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Astrocyte Cell Migration
Negative Regulation By Host Of Viral Transcription
Negative Regulation Of Osteoclast Differentiation
Eosinophil Chemotaxis
Macrophage Chemotaxis
Lymphocyte Chemotaxis
Positive Regulation Of Inflammatory Response
Regulation Of Behavior
Positive Regulation Of Calcium-mediated Signaling
Positive Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Calcium Ion Transport
Regulation Of Sensory Perception Of Pain
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Cholesterol
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Organic Cyclic Compound
Granulocyte Chemotaxis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Microglial Cell Activation
Positive Regulation Of Microglial Cell Migration
Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Chemokine receptors bind chemokines
Interleukin-10 signaling
Drugs
ROX-888
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Body mass index (
26426971
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Blood protein levels (
30072576
29875488
)
Blood protein levels in cardiovascular risk (
28369058
)
Body mass index (
26426971
)
Interacting Genes
28 interacting genes:
ACKR2
ARL13B
CCL3
CCR1
CCR3
CCR5
CCR8
CNR2
CXCL8
GJA8
GPR152
GPRC5D
HRAS
MARCHF2
MRM1
PRRG2
SLC10A6
SLC18A1
SLC30A2
SLC30A8
SLC7A1
TAS2R5
TIMMDC1
TMEM14B
TMEM179B
TMEM31
TMEM86B
UNC93A
12 interacting genes:
ACKR2
CCL4
CCR1
CCR3
CCR4
CCR5
CEBPB
SEC11A
SRGN
TGFB1
UBQLN1
UBQLN2
Entrez ID
6351
6348
HPRD ID
01657
01656
Ensembl ID
ENSG00000275302
ENSG00000277632
Uniprot IDs
P13236
A0N0R1
P10147
PDB IDs
1HUM
1HUN
1JE4
2FFK
2FIN
2X6L
3TN2
4RAL
1B50
1B53
2X69
2X6G
3FPU
3H44
3KBX
4RA8
4ZKB
5COR
5D65
Enriched GO Terms of Interacting Partners
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